Kyle Ribb (Liam Hemsworth) is a drug dealer working for a man only known as Frog (Vince Vaughn). He's "promoted" to Arkansas to move wholesale with a really talkative and overconfident Swin Horn (Clark Duke). While trucking product to Corpus Christi, the rope holding down the flatbed tarp breaks, and they are forced to stop. They meet a ranger (Bright) (John Malkovich) who offers to help. When Kyle points a gun at him, the ranger reveals that he works for Frog and that both Kyle and Swin are going to work under himself at the park. They will cover as Park employees, but will have their main job as delivering drugs to customers when free. They are assigned trailers to live in and are ordered to keep a low profile.They begin working trafficking drugs to different states in the South. Swin meets Johnna (Eden Brolin) and starts dating her despite Bright asking them not to date any locals and keep a low profile. At night, while it rains, Kyle, Swin and Bright drink together as their new orders come. The orders came for a woman called Her (Vivica A. Fox) who lives across the lake in a houseboat. Next, They are to go to Castor in Louisiana now and hand-deliver the product and also collect the payment. Nick (Chandler Duke), the grandson of the buyer looks at Swin and Kyle very angrily as they are rude to his grandpa. Nick follows Kyle and Swin, and finds them handing the money to Bright and leave. Nick waits till they leave, tortures Bright for the money and they both end up killing each other. When Kyle and Swin discover their bodies, Kyle drives over to Castor and kills the buyer and buries Bright in the park. Swin wants to run while Kyle explains that running will only end up with them being dead. They unsuccessfully try to contact Colin, a middleman, to pass up the word.In 1985 Frog, who is the same person who has the pawnshop near the park, is selling tapes from his pawnshop in West Memphis then begins moving drugs. After killing the middleman, he escapes out of West Memphis to Pine Bluff and starts working for a mysterious buyer Almond (Michael Kenneth Williams) who gives him weekly supplies to sell. One day, they go and see the middleman. Dissatisfied with his payout (Almond made $12K, and Frog just $900), Frog sets him up and gets him arrested. He explains to him that is taking over and he's learned a lot from him and amicably asks for the middleman. After some time when the middleman wants out of the game, he sells his wholesaler to Frog, who hesitates at first.Back at the park in present time, Kyle and Swin find a stash of cash near Bright's house. They decide not to touch it and receive another order. They receive an order from Her just like last time. They are paid a visit by Barry, son of a friend of Bright who is there to inform Bright of his friend's passing. He is sent back on his way by Kyle. They both decide to buy guns since their safety is in jeopardy. However, the pawnshop owner is Frog and he doesn't sell guns.Back at the park, while Swin is out jogging, Johnna reveals to Kyle that she is pregnant and that she deduces the two are in trouble in some shady business from all the secrecy. Kyle tells her everything. The next morning, Barry returns asking for Bright. Kyle kills him and buries his body as well. Back in the past, after buying the wholesaler from the middleman, Frog recruits twins Tim (Brad William Henke) and Thomas (Jeff Chase) and recites the same rules as Bright gave Kyle and Swin. Many years later, Frog visits the twins and gives off the business to them telling them that they are ready and he wants to make way for them. He will retire and open up a pawnshop and keep earning a small percentage of the business.In the present time, Kyle and Swin are running the park and waiting for their next orders. Frog is determined to make them pay irrespective of whether they killed Bright or are just covering up mistakes. Frog had sent Barry to investigate the disappearance of Bright and then Barry vanished and the guys further went ahead and scared Her. He gives Her one last package for them to deliver in Hot Springs. At the delivery, they are met by the twins who decide to take matters into their own hands. Thomas takes Swin to execute him while Tim plans on interrogating Kyle about the whereabouts of the stash from Bright's house and Johnna. They get into a struggle and Kyle injures Tim and escapes back to the park to get the money and gives it to Johnna. He tells her that Swin wasn't scared and did not betray him before he died. He gives her the address of Swin's family as they part ways.Frog advises Thomas not to think of revenge and turn back to business as a way of getting past it. Thomas empties out Frog (Thomas had a joint account with Frog and Thomas liquidates everything) and then goes hunting for Kyle. Frog buries Tim in the park and closes his pawnshop, ready to get back in the business. He is met with an injured Kyle, who shoots Frog and takes the contact and phone number of his main drugs supplier from him. Kyle says there is no resigning as a drug dealer.