Architect and happily married man Evan Webber (Keanu Reeves) has the house to himself and his pet French Bulldog Monkey on Father's Day weekend (due to work and a physical therapy appointment due to a shoulder injury) while his wife and children go on a family-planned beach trip. His wife Karen (Ignacia Allamand), a successful artist, leaves their assistant Louis (Aaron Burns) in charge of her sculpture that needs to be moved to an art gallery. Alone in his beautiful and expensive home, Evan works on renderings for an ongoing house project.That evening, two young women, Genesis (Lorenza Izzo) and Bel (Ana de Armas), arrive and knock on his front door. He opens the door and they say that they are looking for the address of a party, but since their phone died, the taxi driver dropped them off. As they have no means of communication, Evan allows them in to use the Internet and get hold of the party's host. Once they find the right address, Evan offers to call an Uber driver for them, but the closest driver will take 45 minutes to arrive. Meanwhile, the girls make themselves at home and Evan plays a few of his old vinyl records he has from when he was a disc jockey. The conversation quickly turns into their opinions about human polygamy and they tell Evan about their jobs as flight attendants as well as how they engage in sexual activity with a new man in every city they fly to. They then disappear to the bathroom and when their Uber driver finally arrives, a circumspect Evan finds them in the bathroom, naked and lusting for him. Outraged, Evan tries to convince them to leave but, as they start forcing themselves upon him, he gives in and has a threesome with them.The following day, Evan finds them eating breakfast and watching Family Feud, not worried at all about leaving. He loses his patience and offers to drive them home, since they have not taken the cab. Evan returns indoors only to find out that his wife's sculpture, which Louis was supposed to collect for the art gallery, has been vandalized. When Evan threatens to call the police, the girls reveal they are underage, showing they have control over him or risk charges on sexual conduct with a minor.Vivian (Colleen Camp), a friend of Karen's, stops by to see if Evan needs help. Seeing Genesis, Vivian angrily leaves, thinking that Evan is cheating on Karen. A shocked Evan tries to make sense of the situation, since he realized that everything the girls had said was a lie in order to get him in bed. When Evan threatens to report a break-in, they give in and agree to be taken home. He drops them off at an upscale neighborhood where they supposedly live.Evan returns home, cleans up the mess, and tries to go back to his work. Just as he is getting closer to completing his project, he hears a shattering noise. He goes looking for the source of the noise, as he is supposedly alone indoors. He finds a picture of his family with the glass broken and Genesis knocks him out with one of his wife's sculptures.The two sinister women bind Evan hand and foot to the bed in a spread-eagle position and go through his family's belongings. Bel climbs on top of him, trying to arouse him while role-playing as a school girl in his daughter's school uniform. Evan initially refuses, but the girls threaten to FaceTime his wife with him in a compromising position with both of them. Even though this disgusts him, Evan realizes that by moving on the bed he can loosen his bonds, so he plays along. Bel semi-rapes him and, unbeknownst to him, Genesis records everything on his phone.A few minutes later, Evan finally frees himself, then jumps at Bel and knocks her off. He charges at Genesis, who stabs him in his wounded shoulder with a fork. She then pins him to the ground and both girls proceed to bind him hand and foot to a chair with electrical cords.Later on, Louis arrives to collect the sculpture Karen left him in charge of. The girls take Evan's phone and text Louis, saying his niece and her friend are staying over. They hide Evan in another room. Louis enters using his keys. He panics upon finding the vandalized sculpture and immediately realizes these girls are lying about their relationship to Evan. Louis then finds Evan bound hand and foot to a chair, but before he can help him he hears the girls smashing the vandalized sculpture. He runs to stop them, but then has an asthma attack, and realizes they have taken his inhaler. The girls play monkey-in-the-middle with his inhaler, and as he tries to get it back, he slips on a piece of the sculpture and knocks his head on the edge of it, killing him.Genesis and Bel turn Louis' corpse into a red sculpture and dig a makeshift grave in the backyard meant for Evan. They also reveal to him that they had been spying on him all along for several days now. He fails in his various attempts to make a 9-1-1 call and to escape from the house. They bind him hand and foot with a garden hose, then bury him in the hole, leaving only his head and neck above ground. Genesis shows Evan the video she recorded earlier with his phone of Bel and him having sex. As a horrified Evan watches, she uploads it to his Facebook profile. Ultimately, they spare Evan's life, going against the idea of killing him in the same fashion they had killed Louis.Revealing that it had all been a "game" and that they are used to tricking fathers into this type of situation, the two sinister women finally depart and take Monkey with them, leaving a broken Evan to his fate while he tries to dig himself out of the hole he is buried in while watching the uploaded video with comments coming in. Karen and the two kids arrive home to find everything in the house destroyed. Evan's son Jake says "Daddy had a party" as Karen remains speechless.