An unexpected series of events turns everyday store clerk Harley (Alex Sharp) into a wanted man; even more unexpectedly, he finds himself on the run with the girl of his dreams (Analeigh Tipton). FBI Agent McFadden [Maria Bello] is determined to crush him and wants to teach her rookie partner (Karan Soni) how it's done. But while the agents pursue their culprit, our hero has loftier pursuits. He kidnaps his Vietnam-vet grandfather (Jeremy Irons) to reunite him with the love of his life, picks up a try-hard beatnik hitchhiker (Edi Gathegi) with his own secret, and against all common sense follows a roadside-attractions map with a mysterious history. As the agents get closer and closer with every stop, this eclectic band of misfits becomes an unlikely family, because sometimes a running start--can be a better start.