Mississippi adolescents Ellis (Tye Sheridan) and Neckbone (Jacob Lofland) are exploring along the mighty Mississippi when they stumble upon a small island inhabited by Mud (Matthew McConaughey), a desperado who claims to be on the run from brutal bounty hunters after killing a man in Texas. According to Mud, his true love Juniper (Reese Witherspoon) is awaiting his arrival in town, and together they plan to make a daring escape. Fascinated, the two boys agree to help Mud slip past his pursuers, despite the potential dangers of doing so..