As rampant, ever-growing pythons infest the warm Florida Everglades thanks to Dr. Nikki Riley's die-hard group of activists, suddenly Park Ranger Terry O'Hara has a lot on her plate. One by one, the slithering invaders are killing the unprepared population of indigenous alligators, leading to a drastic but ill-advised countermeasure: to kill a dangerous predator, one needs to come up with an even more dangerous protector. As a result, gigantic bone-crushing pythons and gargantuan man-eating alligators wreak havoc on the land, devouring everything in their path. Now, the ultimate battle between two species commences, and whichever one wins, humans lose. Can Nikki and Terry put aside their differences in the name of survival?—Nick Riganas