Gopal (Ajay Devgn) lives with his wife Ekta (Kareena Kapoor), who is addicted to watching Indian dramas. He also lives with sister Esha (Amrita Arora) and a mute brother-in-law Lucky (Tusshar Kapoor) (Ekta is Lucky's sister). Lucky is in love with a deaf girl named Daisy (Anjana Sukhani). Gopal works at a seafood processing plant with co-worker Subodh (Sanjay Mishra) (who leaves no opportunity to stoke suspicion in Ekta), Julie (Rakhee Tandon) (his personal secy), Babloo (Sharat Saxena) (owner of the company) and Sawant (Murali Sharma) (MD of the company). Babloo wants all his employees to be fit and young and has his guns trained on Gopal.In addition, police officer Madhav (Arshad Warsi) suspects Gopal's firm of dealing with drugs distribution using its fishing fleet. But he has no proof and all efforts to gather are thwarted by Gopal.One night, while returning from his office, Gopal saves an attractive young woman named Meera (Celina Jaitly) from some dreadful goons. Due to the circumstances, both of them decide to spend the night at Gopal's friend's yacht.Meanwhile Madhav finds that Subodh was killed by someone brutally and the suspicion goes on Gopal who hated Subodh.When he arrives home the next day, his over-suspicious wife suspects him of flirting around with his female employees and having an affair with his secretary. Knowing how difficult it is to convince her with the truth, he invents a story about spending the night with a fictitious friend named Anthony Gonsalves. Ekta becomes suspicious and does not believe his story as she knows that he never had a friend by that name, and hence, she decides to write to Anthony visit her and to confirm Gopal was telling the truth.Gopal meets Laxman Prasad (Shreyas Talpade) who has come to interview for a position in his office. He is Meera's boyfriend, which is not known to Gopal who asks him to pretend to be Anthony and meet and convince Ekta that he was indeed telling the truth, in return for a job. Laxman agrees to do so, and everything goes according to plan until the address on which Ekta had written a letter to Anthony (Vrajesh Hirjee) turns out to be real. But the letter is intercepted by Anthony's wife Julie who meets Ekta as she thinks Anthony is having an affair with Ekta. Anthony later comes to meet Ekta but is intercepted and thrashed by Gopal, Laxman and lucky. Meanwhile, Gopal finds out that a dead body was found at the same location where he saved Meera from the goons. Laxman turns out to be Meera's boyfriend.Investigating Officer Madhav (Arshad Warsi), who also happens to be Esha's boyfriend, does not get along with Gopal. He finds out that Gopal was missing from his home that very night and that the dead person was Gopal's colleague Subodh whom he had threatened to kill over a spat. Gopal sends Laxman as Anthony to Madhav to give evidence that Gopal was with Anthony that night.Ekta sees Laxman with Meera and goes to Antony's house and meets Julie and the real Anthony. She tells Madhav.Madhav also finds out that Laxman is not the real Anthony. Gopal tells Madhav the truth. He asks Gopal to get Meera to the police station to prove that Gopal had been with her and did not murder his employee. After three days and a lot of attempts, they still are not able to find Meera. In panic, Laxman and Lucky hire a woman called Munni (Ashwini Kalsekar) who needs money to get her boyfriend Vasooli (Mukesh Tiwari) out of jail, to pose as Meera. But Munni is kidnapped by the murderer. The murderer leaves a note by Munni to Madhav saying that Gopal wanted her to lie and that he had defrauded the company and killed Subodh when he found out.In a rage, Vasooli comes to Meera's house, where Laxman and Lucky learn the woman was none other than Meera whom Gopal had saved from the goons that night. After an initial shock, they decide to go to the police station. However, Vasooli kidnaps Meera in anger. Gopal is later bailed out by Sawant (Murali Sharma) who is going along with him to the Lover's Point along with Madhav, Esha, Lucky and Laxman in tow and Ekta, Vasooli and Meera arriving later. Munni is found tied up with her mouth gagged with tape in the back of the murderer's jeep. Munni is heard moaning through the tape on her mouth. Laxman unties Munni and removes the tape from her mouth.Gopal learns that this was a plot concocted by Sawant to frame him for the murder. Subodh had found that Sawant was exporting drugs using the fishing fleet, so Sawant had him killed and now wants to frame Gopal, by getting him to admit to smuggling and killing Subodh and committing suicide. The drama grows, as everyone attempts suicide (except Madhav and Lucky), much to Sawant's anger. Finally, Sawant goes crazy and kills himself. Ekta and Gopal get back together in the end. Lucky meanwhile marries the daughter of the president of Gopal's company who happens to be Daisy and becomes the new boss, giving a shock to the others. Gopal and Laxman are the junior bosses while Madhav is a 24-hour guard for Lucky.