A wanted murderer, Billy John (James Best), is captured by Ben Brigade (Randolph Scott), a bounty hunter, who intends to take him to Santa Cruz to be hanged. Brigade stops at a staging post, where he saves the manager's wife (Karen Steele) from an Indian attack, and enlists the help of two outlaws (Pernell Roberts, James Coburn) to continue his journey more safely. However, the Indian attacks persist, the outlaws plan to take Billy for themselves, tempted by the offer of amnesty for his captor, and Billy's brother Frank (Lee Van Cleef) is in hot pursuit to rescue him. But Brigade has plans of his own..—David Levene